Lungs And Nodules Segmentation from Computed Tomography Scans Using Auxiliary U-Net
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How to Cite

yahyaouy, Abderrahim El, Abdelkader Hadjoudja, Abdelmajid EL Moutaouakkil, Rachida Latib, Youssef Omor, and Hamza Retal. 2025. “Lungs And Nodules Segmentation from Computed Tomography Scans Using Auxiliary U-Net”. Journal of Innovative Image Processing 7 (4): 1320-38. https://doi.org/10.36548/jiip.2025.4.013.

Keywords

  • LUNA16
  • Lung Nodules
  • Segmentation
  • Auxiliary Loss
  • Squeeze and Excitation Block
  • U-Net

Abstract

Due to the increasing prevalence of lung cancer and the urgent need for artificial intelligence technologies to support medical fields, there is an immediate demand for highly accurate and dependable automated diagnostic models for the segmentation of chest CT scans. Accurate segmentation will reduce clinicians' manual labor and improve diagnostic results. This paper proposes a new segmentation model, which combines an improved U-Net architecture with a squeeze-and-excitation mechanism. The model can utilize the loss in a multilevel fashion, thanks to the auxiliary classification at the bottleneck layer. Furthermore, the squeeze-and-excitation block focuses on the key characteristics extracted from convolutional layers. Experiments on the LUNA16 dataset were carried out to train and evaluate the model. The proposed approach outperformed many other segmentation methods and was very effective in defining the shape of lung nodules more precisely. On the LUNA16 dataset, it achieved 98.42% DSC and 98.56% accuracy. It has been proven that the segmentation of lung nodules in chest CT scans using an auxiliary U-Net architecture together with a squeeze-and-excitation mechanism is highly efficient and cost-effective. High accuracy and Dice coefficient against the most advanced segmentation models demonstrate the possibility of clinical usage and provide accurate boundary detection, which is crucial for an accurate diagnosis and treatment. The proposed contraction and stimulation mechanism with an auxiliary U-Net architecture has achieved very effective yet inexpensive lung nodule segmentation on chest CT scans, compared to state-of-the-art segmentation models. Accurate identification of the boundaries is of paramount importance for diagnosis and treatment planning, and the high Dice coefficient and accuracy support its use in clinical settings.

References

Siegel, Rebecca L., Kimberly D. Miller, Hannah E. Fuchs, and Ahmedin Jemal. "Cancer Statistics, 2022." CA: a cancer journal for clinicians 72, no. 1 (2022). 7-33.

Gu, Yu, Jingqian Chi, Jiaqi Liu, Lidong Yang, Baohua Zhang, Dahua Yu, Ying Zhao, and Xiaoqi Lu. "A Survey of Computer-Aided Diagnosis of Lung Nodules from CT Scans Using Deep Learning." Computers in biology and medicine 137 (2021): 104806.

Hua, Kai-Lung, Che-Hao Hsu, Shintami Chusnul Hidayati, Wen-Huang Cheng, and Yu-Jen Chen. "Computer-Aided Classification of Lung Nodules on Computed Tomography Images via Deep Learning Technique." OncoTargets and therapy (2015): 2015-2022.

Zheng, Sunyi, Ludo J. Cornelissen, Xiaonan Cui, Xueping Jing, Raymond NJ Veldhuis, Matthijs Oudkerk, and Peter MA van Ooijen. "Deep Convolutional Neural Networks for Multiplanar Lung Nodule Detection: Improvement in Small Nodule Identification." Medical physics 48, no. 2 (2021): 733-744.

Samuel, G “The Lung Image Database Consortium (LIDC) and Image Database Resource Initiative (IDRI): A Completed Reference Database of Lung Nodules on CT Scans” Medical Physics, (2011): 38, 915-931.

Setio, Arnaud Arindra Adiyoso, Alberto Traverso, Thomas De Bel, Moira SN Berens, Cas Van Den Bogaard, Piergiorgio Cerello, Hao Chen et al. "Validation, Comparison, and Combination of Algorithms for Automatic Detection Of Pulmonary Nodules in Computed Tomography Images: The LUNA16 Challenge." Medical image analysis 42 (2017): 1-13.

National Lung Screening Trial Research Team. "Reduced Lung-Cancer Mortality with Low-Dose Computed Tomographic Screening." New England Journal of Medicine 365, no. 5 (2011): 395-409.

Zhao, Ying Ru, Xueqian Xie, Harry J. De Koning, Willem P. Mali, Rozemarijn Vliegenthart, and Matthijs Oudkerk. "NELSON Lung Cancer Screening Study." Cancer Imaging 11, no. 1A (2011): S79-84.

Nam, Chang-Mo, Jihang Kim, and Kyong Joon Lee. "Lung Nodule Segmentation with Convolutional Neural Network Trained by Simple Diameter Information." (2018).

Asha, V., and K. Bhavanishankar. "Advanced Lung Nodule Segmentation and Classification for Early Detection of Lung Cancer using SAM and Transfer Learning." https://arxiv.org/abs/2501.00586

Zafaranchi, Arman, Francesca Lizzi, Alessandra Retico, Camilla Scapicchio, and Maria Fantacci. "Explainability Applied to a Deep-Learning Based Algorithm for Lung Nodule Segmentation." In Proceedings of the 1st International Conference on Explainable AI for Neural and Symbolic Methods-EXPLAINS, vol. 1, Scitepress, 2024, 132-138.

Li, Ai-Hsien Adam, Cristian Daniel Aruperes, Yen-Jun Lai, Ting-Ying Chien, Yen-Ling Chiu, and Chien-Lung Chan. "Lung Nodule Analysis in CT Images: Deep Learning for Segmentation and Measurement." In Proceedings of the 2024 8th International Conference on Medical and Health Informatics, 2024, 13-17.

Bhattacharyya, Debnath, N. Thirupathi Rao, Eali Stephen Neal Joshua, and Yu-Chen Hu. "A Bi-Directional Deep Learning Architecture for Lung Nodule Semantic Segmentation." The Visual Computer 39, no. 11 (2023): 5245-5261.

Li, Yuemeng, and Yang Fan. "DeepSEED: 3D Squeeze-and-Excitation Encoder-Decoder Convolutional Neural Networks for Pulmonary Nodule Detection." In 2020 IEEE 17th International Symposium on Biomedical Imaging (ISBI), IEEE, 2020, 1866-1869.

Dou, Qi, Hao Chen, Lequan Yu, Jing Qin, and Pheng-Ann Heng. "Multilevel Contextual 3-D CNNs for False Positive Reduction in Pulmonary Nodule Detection." IEEE Transactions on Biomedical Engineering 64, no. 7 (2016): 1558-1567.