Click-To-Clinic: A Deep Learning–Based Web Application for Parkinson’s Disease Detection Using MRI Images
Parkinson's disease (PD) is an increasing neurodegenerative disease complicated to detect early due to basic symptoms of disease and the complexities of evaluating neuroimaging data. The recent deep learning algorithms showed automatic PD detection from MRI scans. In previous studies, there is limited offline testing and lack of portable, usable end-to-end screening solutions makes it difficult to prevent the disease early. This proposed work represents a lightweight web-based platform combining standardized MRI preprocessing, advanced convolutional neural network (CNN) and real-time prediction using a flask implementation process. The Gradient-weighted Class Activation Mapping (Grad-CAM) provides graphical representation of brain areas affecting the classification decisions with improved model visibility. The proposed approach is evaluated using publicly available MRI dataset. The results show better performance of 97% classification accuracy, equal precision, recall and F1-score leads to accurate detection of Parkinson's disease and normal control cases under controlled dataset conditions. However, class imbalance, dataset size and a lack of imaging-source variety have an impact on performance. As a result, this research presents a reusable research model and experimental system instead of a clinically proven diagnostic tool. Future study will focus on cross-dataset validation, improved data balancing techniques and detailed comparisons to existing machine learning and transfer-learning algorithms.
@article{v.2026,
author = {Rathinapriya V. and Shiny Zerubba Rajive S. and Sooriyavani A. and Sooriyaveena A.},
title = {{Click-To-Clinic: A Deep Learning–Based Web Application for Parkinson’s Disease Detection Using MRI Images}},
journal = {Journal of Soft Computing Paradigm},
volume = {8},
number = {1},
pages = {17-44},
year = {2026},
publisher = {IRO Journals},
doi = {10.36548/jscp.2026.1.002},
url = {https://doi.org/10.36548/jscp.2026.1.002}
}
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- Dorsey, ERlet al, R. Constantinescu, J. P. Thompson, K. M. Biglan, R. G. Holloway, K. Kieburtz, F. J. Marshall et al. "Projected Number of People with Parkinson Disease in the Most Populous Nations, 2005 Through 2030." Neurology 68, no. 5 (2007): 384-386.
- Chaudhuri, K. Ray, Daniel G. Healy, and Anthony HV Schapira. "Non-Motor Symptoms of Parkinson's Disease: Diagnosis and Management." The Lancet Neurology 5, no. 3 (2006): 235-245.
- Kalia, Lorraine V., and Anthony E. Lang. "Parkinson's Disease." The lancet 386, no. 9996 (2015): 896-912.
- Goetz, Christopher G., Barbara C. Tilley, Stephanie R. Shaftman, Glenn T. Stebbins, Stanley Fahn, Pablo Martinez‐Martin, Werner Poewe et al. "Movement Disorder Society‐Sponsored Revision of the Unified Parkinson's Disease Rating Scale (MDS‐UPDRS): Scale Presentation and Clinimetric Testing Results." Movement disorders: official journal of the Movement Disorder Society 23, no. 15 (2008): 2129-2170.
- LeCun, Yann, Yoshua Bengio, and Geoffrey Hinton. "Deep Learning." nature 521, no. 7553 (2015): 436-444.
- Vyas, Tarjni, Raj Yadav, Chitra Solanki, Rutvi Darji, Shivani Desai, and Sudeep Tanwar. "Deep Learning‐Based Scheme to Diagnose Parkinson's Disease." Expert Systems 39, no. 3 (2022): e12739.
- Liu, Xiao-ge, Shuai Lu, Dong-qun Liu, Lun Zhang, Ling-xiao Zhang, Xiao-lin Yu, and Rui-tian Liu. "ScFv-Conjugated Superparamagnetic Iron Oxide Nanoparticles for MRI-Based Diagnosis in Transgenic Mouse Models of Parkinson’s and Huntington’s Diseases." Brain research 1707 (2019): 141-153.
- Eunus, Salman Ibne, Sakib Rokoni, Mitheela Das Armisha, Jasia Hossain Omi, Asika Islam, and Farah Binta Haque. "Hybrid 3D CNN-LSTM Model for rs-fMRI-Based Parkinson’s Prediction." Journal of Independent Studies and Research Computing 23, no. 1 (2025): 8-15.
- Skaramagkas, Vasileios, Anastasia Pentari, Zinovia Kefalopoulou, and Manolis Tsiknakis. "Multi-Modal Deep Learning Diagnosis of Parkinson’s Disease—A Systematic Review." IEEE Transactions on Neural Systems and Rehabilitation Engineering 31 (2023): 2399-2423.
- Uzzaman, Asad, AFM Nazmus Sakib, Sanjida Ali Shushmita, SM Ashraf Kabir, Md Tanzim Reza, and Mohammad Zavid Parvez. "Parkinson’s Disease Detection Using FMRI Images Leveraging Transfer Learning on Convolutional Neural Network." In 2020 International Conference on Machine Learning and Cybernetics (ICMLC), IEEE, 2020, 131-136.
- El Ariss, Omar, and Kaoning Hu. "ResNet-Based Parkinson's Disease Classification." IEEE Transactions on Artificial Intelligence 4, no. 5 (2022): 1258-1268.
- Im Abukaresh, ALaa, and Ali Okatan. "AI-Based Early Detection of Parkinson's Disease Using MRI: A Comparative Analysis of Densenet121 and Resnet Models." EURAS JOURNAL OF ENGINEERING AND APPLIED SCIENCES Учредители: Istanbul Aydin University 4, no. 2 (2021): 81-117.
- Islam, Md Ariful, Md Ziaul Hasan Majumder, Md Alomgeer Hussein, Khondoker Murad Hossain, and Md Sohel Miah. "A Review of Machine Learning and Deep Learning Algorithms for Parkinson's Disease Detection Using Handwriting and Voice Datasets." Heliyon 10, no. 3 (2024).
- Balakrishnan, Aishwarya, Jeevan Medikonda, and Pramod Kesavan Namboothiri. "Role of Wearable Sensors with Machine Learning Approaches in Gait Analysis for Parkinson's Disease Assessment: A Review." Engineered Science 19, no. 13 (2022): 5-19.
- Hoehn, Margaret M., and Melvin D. Yahr. "Parkinsonism: Onset, Progression, and Mortality." Neurology 17, no. 5 (1967): 427-427.

